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1

Length dependence of RNA-RNA annealing

Volker Patzel, Georg Sczakiel

Journal:

Journal of Molecular Biology

Year:

1999

Language:

english

File:

PDF, 220 KB

english, 1999

2

Local RNA Target Structure Influences siRNA Efficacy: A Systematic Global Analysis

Marita Overhoff, Martina Alken, Rosel Kretschmer-Kazemi Far, Marc Lemaitre, Bernard Lebleu, Georg Sczakiel, Ian Robbins

Journal:

Journal of Molecular Biology

Year:

2005

Language:

english

File:

PDF, 327 KB

english, 2005

3

Replication of the human immunodeficiency virus type 1 is inhibited by the adeno-associated virus rep gene

RITTNER, KAROLA, HEILBRONN, REGINE, KLEINSCHMIDT, JÜRGEN A., OELZE, INGO, SCZAKIEL, GEORG

Journal:

Biochemical Society Transactions

Year:

1991

Language:

english

File:

PDF, 101 KB

english, 1991

4

Spezifische Proteinerkennung durch Array-gebundene Hexanukleotide

Dr. Alessandra Mescalchin, Winfried Wünsche, Prof. Dr. Georg Sczakiel

Journal:

Angewandte Chemie

Year:

2011

Language:

german

File:

PDF, 452 KB

german, 2011

5

Inhibition of Ki-67 in a renal cell carcinoma severe combined immunodeficiency disease mouse model is associated with induction of apoptosis and tumour growth inhibition

Ingo Kausch, Hai Jiang, Nina Ewerdwalbesloh, Christian Doehn, Stefan Krüger, Georg Sczakiel, Dieter Jocham

Journal:

BJU International

Year:

2005

Language:

english

File:

PDF, 384 KB

english, 2005

6

Synthesis and Preliminary Evaluation of pro-RNA 2′- O -Masked with Biolabile Pivaloyloxymethyl Groups in an RNA Interference Assay

Lavergne, Thomas, Baraguey, Carine, Dupouy, Christelle, Parey, Nora, Wuensche, Winfried, Sczakiel, Georg, Vasseur, Jean-Jacques, Debart, Françoise

Journal:

Journal of Organic Chemistry

Year:

2011

Language:

english

File:

PDF, 1.42 MB

english, 2011

7

In vitro selection of fast-hybridizing and effective antisense RNAs directed against the human immunodeficiency virus type 1

Rittner, Karola, Burmester, Christoph, Sczakiel, Georg

Journal:

Nucleic Acids Research

Year:

1993

Language:

english

File:

PDF, 4.04 MB

english, 1993

8

Incorporation of the catalytic domain of a hammerhead ribozyme into antisense RNA enhances its inhibitory effect on the replication of human immunodeficiency virus type 1

Homann, Matthias, Tzortzakaki, Sergia, Rittner, Karola, Sczakiel, Georg, Tabler, Martin

Journal:

Nucleic Acids Research

Year:

1993

Language:

english

File:

PDF, 3.74 MB

english, 1993

9

Reduction in Replication of the Human Immunodeficiency Virus Type 1 in Human T Cell Lines by Polymerase III-Driven Transcription of Chimeric tRNA—Antisense RNA Genes

JUNKER, UWE, RITTNER, KAROLA, HOMANN, MATTHIAS, BEVEC, DORIAN, BÖHNLEIN, ERNST, SCZAKIEL, GEORG

Journal:

Antisense Research and Development

Year:

1994

Language:

english

File:

PDF, 3.81 MB

english, 1994

10

Phosphorothioate-stimulated uptake of short interfering RNA by human cells

Overhoff, Marita, Sczakiel, Georg

Journal:

Year:

2005

Language:

english

File:

PDF, 164 KB

english, 2005

11

Disinfection of cell-associated and extracellular HIV-1 by PUVA treatment

Martin Deichmann, Georg Sczakiel, Rainer Haas

Journal:

Journal of Virological Methods

Year:

1997

Language:

english

File:

PDF, 529 KB

english, 1997

12

Editorial: Die Lebenswissenschaften durch die Brille der Chemie betrachtet: Erprobte Denkweisen auf neuartige Entwicklungen anwenden

Journal:

Chemie in unserer Zeit

Year:

2004

Language:

german

File:

PDF, 64 KB

german, 2004

13

Expression of native rabbit light meromyosin in Escherichia coli

Maeda, Kayo, Sczakiel, Georg, Hofmann, Waltraud, Menetret, Jean-Francois, Wittinghofer, Alfred

Journal:

Journal of Molecular Biology

Year:

1989

Language:

english

File:

PDF, 680 KB

english, 1989

14

Identification and analysis of antisense RNA target regions of the human immunodeficiency virus type 1

Rittner, Karola, Sczakiel, George

Journal:

Nucleic Acids Research

Year:

1991

Language:

english

File:

PDF, 1.01 MB

english, 1991

15

Mini-Chiuz

Dieter Wöhrle, Dr. E. Marti, A. Müller, E. Krahn, Roland Kreutzer, Jürgen A. Kelinschmidt, Georg Sczakiel, L. Jaenicke, Rainer Flöbl, Achim Müller

Journal:

Chemie in unserer Zeit

Year:

1993

Language:

german

File:

PDF, 1.87 MB

german, 1993

16

Kinetic Selectivity of Complementary Nucleic Acids:bcr-abl-directed Antisense RNA and Ribozymes

Ralf Kronenwett, Rainer Haas, Georg Sczakiel

Journal:

Journal of Molecular Biology

Year:

1996

Language:

english

File:

PDF, 836 KB

english, 1996

17

Implications of RNA Structure on the Annealing of a Potent Antisense RNA Directed against the Human Immunodeficiency Virus Type 1 †

Eckardt, Sigrid, Romby, Pascale, Sczakiel, Georg

Journal:

Year:

1997

Language:

english

File:

PDF, 546 KB

english, 1997

18

Specific Recognition of Proteins by Array-Bound Hexanucleotides

Dr. Alessandra Mescalchin, Winfried Wünsche, Prof. Dr. Georg Sczakiel

Journal:

Angewandte Chemie International Edition

Year:

2011

Language:

english

File:

PDF, 432 KB

english, 2011

19

The Activity of siRNA in Mammalian Cells is Related to the Kinetics of siRNA-target Recognition In Vitro: Mechanistic Implications

Winfried Wünsche, Georg Sczakiel

Journal:

Journal of Molecular Biology

Year:

2005

Language:

english

File:

PDF, 214 KB

english, 2005

20

The Association of Complementary Ribonucleic Acids Can Be Strongly Increased without Lowering Arrhenius Activation Energies or Significantly Altering Structures †

Nedbal, Wolfgang, Homann, Matthias, Sczakiel, Georg

Journal:

Year:

1997

Language:

english

File:

PDF, 217 KB

english, 1997

21

Specific inhibition of human immunodeficiency virus type 1 replication by RNA transcribed in sense and antisense orientation from the 5′-leader/gag region

Georg Sczakiel, Michael Pawlita, Andreas Kleinheinz

Journal:

Biochemical and Biophysical Research Communications

Year:

1990

Language:

english

File:

PDF, 686 KB

english, 1990

22

Electrotransfection of human lymphoid and myelold cell lines

Döffinger, Rainer, Pawlita, Michael, Sczakiel, Georg

Journal:

Nucleic Acids Research

Year:

1988

Language:

english

File:

PDF, 908 KB

english, 1988

23

A hexanucleotide selected for increased cellular uptake in cis contains a highly active CpG-motif in human B cells and primary peripheral blood mononuclear cells

Miriam Mende, Anne Hopert, Winfried Wünsche, Marita Overhoff, Anke Detzer, Kirsten Börngen, Peter Schlenke, Holger Kirchner, Georg Sczakiel

Journal:

Year:

2007

Language:

english

File:

PDF, 740 KB

english, 2007

24

A robust methodology to study urine microRNA as tumor marker: microRNA-126 and microRNA-182 are related to urinary bladder cancer

Merle Hanke, Kai Hoefig, Hartmut Merz, Alfred C. Feller, Ingo Kausch, Dieter Jocham, Jens M. Warnecke, Georg Sczakiel

Journal:

Urologic Oncology: Seminars and Original Investigations

Year:

2010

Language:

english

File:

PDF, 590 KB

english, 2010

25

Direct Synthesis of Partially Modified 2′- O -Pivaloyloxymethyl RNAs by a Base-Labile Protecting Group Strategy and their Potential for Prodrug-Based Gene-Silencing Applications

Biscans, Annabelle, Bos, Maxence, Martin, Anthony R., Ader, Nicholas, Sczakiel, Georg, Vasseur, Jean-Jacques, Dupouy, Christelle, Debart, Françoise

Journal:

Year:

2014

Language:

english

File:

PDF, 540 KB

english, 2014

26

Theoretical and Experimental Approaches to Design Effective Antisense Oligonucleotides

Sczakiel, Georg

Journal:

Frontiers in Bioscience

Year:

2000

File:

PDF, 60 KB

2000

27

Technical Improvements in the Computational Target Search for Antisense Oligonucleotides

Far, Rosel Kretschmer-Kazemi, Leppert, Jan, Frank, Kirsten, Sczakiel, Georg

Journal:

Oligonucleotides

Year:

2005

Language:

english

File:

PDF, 126 KB

english, 2005

28

“Chemie in unserer Zeit” in der Stadt der Wissenschaft 2012

Professor Dr. Georg Sczakiel

Journal:

Chemie in unserer Zeit

Year:

2012

Language:

german

File:

PDF, 80 KB

german, 2012

29

Fast Rna-Rna Annealing in Vitro: Single Cycle Selection Versus Multiple Cycle Selection

Patzel, Volker, Kronenwett, Ralf, Rittner, Karola, Sczakiel, Georg

Journal:

Nucleosides and Nucleotides

Year:

1997

Language:

english

File:

PDF, 205 KB

english, 1997

30

Theoretical and Experimental Approaches to Design Effective Antisense Oligonucleotides

Sczakiel, Georg

Journal:

Frontiers in Bioscience

Year:

2000

Language:

english

File:

PDF, 60 KB

english, 2000

31

Die räumliche Struktur von Hammerhead-Ribozymen

Priv.-Doz. Dr. Georg Sczakiel

Journal:

Angewandte Chemie

Year:

1995

Language:

german

File:

PDF, 434 KB

german, 1995

32

Design of effective antisense — oligonucleotides for science and medicine

Thomas Meyer, Georg Sczakiel, Wolfgang Nedbal

Journal:

European Journal of Cancer

Year:

2001

Language:

english

File:

PDF, 55 KB

english, 2001

33

The Three-Dimensional Structure of Hammerhead Ribozymes

Dr. Georg Sczakiel

Journal:

Angewandte Chemie International Edition

Year:

1995

Language:

english

File:

PDF, 369 KB

english, 1995

34

Wie Gene abgelesen werden

Tobias Restle, Georg Sczakiel

Journal:

Chemie in unserer Zeit

Year:

2006

Language:

german

File:

PDF, 277 KB

german, 2006

35

Concentrations of Circulating RNA from Healthy Donors and Cancer Patients Estimated by Different Methods

ELENA Y. RYKOVA, WINFRIED WUNSCHE, OLGA E. BRIZGUNOVA, TATYANA E. SKVORTSOVA, SVETLANA N. TAMKOVICH, ILIJA S. SENIN, PAVEL P. LAKTIONOV, GEORG SCZAKIEL, VALENTIN V. VLASSOV

Journal:

Annals of the New York Academy of Sciences

Year:

2006

Language:

english

File:

PDF, 137 KB

english, 2006

36

Hammerhead Ribozyme Activity in the Presence of Low Molecular Weight Cellular Extract

NEDBAL, WOLFGANG, SCZAKIEL, GEORG

Journal:

Antisense and Nucleic Acid Drug Development

Year:

1997

Language:

english

File:

PDF, 2.73 MB

english, 1997

37

Nonstructural Proteins 7 and 8 of Feline Coronavirus Form a 2:1 Heterotrimer That Exhibits Primer-Independent RNA Polymerase Activity

Xiao, Yibei, Ma, Qingjun, Restle, Tobias, Shang, Weifeng, Svergun, Dmitri I., Ponnusamy, Rajesh, Sczakiel, Georg, Hilgenfeld, Rolf

Journal:

Journal of Virology

Year:

2012

Language:

english

File:

PDF, 2.68 MB

english, 2012

38

Extension of helix II of an HIV-1-directed hammerhead ribozyme with long antisense flanks does not alter kinetic parameters in vitro but causes loss of the inhibitory potential in living cells

Homann, Matthias, Tabler, Martin, Tzortzakaki, Sergia, Sczakiel, Georg

Journal:

Nucleic Acids Research

Year:

1994

Language:

english

File:

PDF, 4.33 MB

english, 1994

39

Lipophilic 2'-O-Acetalester RNAs:Synthesis, Thermal Duplex Stability, Nuclease Resistance, Cellular Uptake and siRNA Activity after Spontaneous Naked Delivery

Biscans, Annabelle, Bertrand, Jean-Rémi, Dubois, Josephine, Rüger, Jacqueline, Vasseur, Jean-Jacques, Sczakiel, Georg, Dupouy, Christelle, Debart, Francoise

Journal:

Year:

2016

Language:

english

File:

PDF, 1.24 MB

english, 2016

40

The Hepatitis B Virus Posttranscriptional Regulatory Element Contains a Highly Stable RNA Secondary Structure

Volker Patzel, Georg Sczakiel

Journal:

Biochemical and Biophysical Research Communications

Year:

1997

Language:

english

File:

PDF, 106 KB

english, 1997

41

Theoretical design of antisense RNA structures substantially improves annealing kinetics and efficacy in human cells

Patzel, Volker, Sczakiel, Georg

Journal:

Nature Biotechnology

Year:

1998

File:

PDF, 659 KB

1998

42

[Methods in Enzymology] Recombinant DNA Part H Volume 217 || [1] Vector pPLEX for expression of nonfusion polypeptides in Escherichia coli

Sczakiel, Georg

Year:

1993

Language:

english

File:

PDF, 1.19 MB

english, 1993

43

Activity and Stability of Hammerhead Ribozymes Containing 2′-C-Methyluridine: a New RNA Mimic

Mariana Gallo, Rosel Kretschmer-Kazemi Far, Georg Sczakiel, Adolfo M. Iribarren

Journal:

Chemistry & Biodiversity

Year:

2005

Language:

english

File:

PDF, 72 KB

english, 2005

44

In vitro and in vivo action of antisense RNA

Wolfgang Nellen, Georg Sczakiel

Journal:

Molecular Biotechnology

Year:

1996

Language:

english

File:

PDF, 1.08 MB

english, 1996

45

The Design of Antisense RNA

SCZAKIEL, GEORG

Journal:

Antisense and Nucleic Acid Drug Development

Year:

1997

Language:

english

File:

PDF, 2.35 MB

english, 1997

46

Oligodeoxyribonucleotide Uptake in Primary Human Hematopoietic Cells Is Enhanced by Cationic Lipids and Depends on the Hematopoietic Cell Subset

Kronenwett, Ralf, Steidl, Ulrich, Kirsch, Michael, Sczakiel, Georg, Haas, Rainer

Journal:

Year:

1998

Language:

english

File:

PDF, 376 KB

english, 1998

47

Purification and Characterization of an Active Form of the p78RepProtein of Adeno-associated Virus Type 2 Expressed inEscherichia coli

Volker Wollscheid, Manfred Frey, Hanswalter Zentgraf, Georg Sczakiel

Journal:

Protein Expression and Purification

Year:

1997

Language:

english

File:

PDF, 1.08 MB

english, 1997

48

Antisense RNA-Mediated Inhibition of the Replication of the Human Immunodeficiency Virus Type 1. : Discussion of Critical Parameters

GEORG SCZAKIEL, MICHAEL PAWLITA, KAROLA RITTNER, MATTHIAS HOMANN

Journal:

Annals of the New York Academy of Sciences

Year:

1992

Language:

english

File:

PDF, 142 KB

english, 1992

49

Cellular uptake and intracellular release are major obstacles to the therapeutic application of siRNA: novel options by phosphorothioate-stimulated delivery

Mescalchin, Alessandra, Detzer, Anke, Wecke, Maria, Overhoff, Marita, Wünsche, Winfried, Sczakiel, Georg

Journal:

Expert Opinion on Biological Therapy

Year:

2007

Language:

english

File:

PDF, 481 KB

english, 2007

50

MicroRNA-mediated regulation of gene expression is affected by disease-associated SNPs within the 3′-UTR via altered RNA structure

Haas, Ulrike, Sczakiel, Georg, Laufer, Sandra

Journal:

Year:

2012

Language:

english

File:

PDF, 1.06 MB

english, 2012

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